Well, for those of you who have been wondering, we got the go-ahead this past week to begin a new
IVF cycle. Dr. Dunn has ordered a new protocol this time around, different from anything we have tried before. It's called a "flare protocol," and it is much more aggressive as far as the number of eggs it will (hopefully) yield. For you techies who actually care about this stuff, here is how it works, according to
http://www.ivf.ca/flare.htm:
In this type of stimulation, the
Lupron (or other
GnRH agonist) is started on cycle day 2 in the same menstrual cycle that eggs will be retrieved - instead of starting it a week prior to the start of menses. This protocol takes advantage of an initial "flare-up" response of
FSH and
LH release from the woman's own pituitary gland that usually occurs in the first 3 days of
Lupron administration. Continuing
Lupron for more than 3 days temporarily suppresses the pituitary gland so that it has very low output of
FSH and
LH.The
FSH product (e.g.
Follistim,
Gonal-F,
Repronex) is then started on the following day (day 3).
Lupron will stimulate release of a large amount of
FSH (and
LH) that will jump-start (flare-up) the follicles to promote a better ovarian stimulation, with more mature follicles and more eggs to utilize with
IVF.Birth control pills are usually given for the month before the flare so that there will not be a leftover cyst (corpus
luteum) that could become reactivated by the high
LH levels at the onset of the flare stimulation.There are variations to the protocol. This is one example:
1. Birth control pills for 1 month (I will be taking them for three weeks, starting 2/22.)
2. Stop birth control pills - no
meds for 2 days
3. Start
Lupron on the third pill free day. We use a 50
ug dose of
Lupron twice daily -AM and PM- for these flare cycles. 50
ug is a very small dose as compared to the usual Long
Lupron protocol dose of 0.5mg (500
ug). The
Lupron needs to be diluted by the pharmacy or the doctor's office in order to be able to inject such a low dose.
4. Start injections of the
FSH product (once or twice daily) on the day after starting
Lupron5. The
Lupron is usually continued at the same dose until the
HCG trigger shot is given.
Our egg retrieval is tentatively scheduled for March 30; and if all goes according to plan, our embryo transfer will happen 5 days later. I should be able to get an accurate
HPT result by my birthday on April 14. HAPPY BIRTHDAY TO ME (I hope)!!!